Professional Info

Prof. BLOCKI, Anna Maria

(Assistant Professor)

Personal Information

Assistant Professor of the Institute for Tissue Engineering and Regenerative Medicine

Office: (852) 3943 9797
Address: Room 124A, 1/F, Lo Kwee-Seong Integrated Biomedical Science Building, Area 39, CUHK

Research Interest

The research interest of Prof. Blocki includes the design of bio-instructive materials with properties that go well beyond mere cell support and tolerance by host tissues upon implantation. By tapping into nature’s wisdom and learning about the mechanisms of how the extracellular matrix conveys its messages, Prof. Blocki strives to develop bio-instructive materials, which will guide endogenous regenerative processes upon implantation.

Her other research interest is on cell-based therapy focusing on blood-derived angiogenic cells (BDACs). These BDACs were previously engineered to meet the clinical requirements on quantity and necessity of short-term availability. Their regenerative effect, as previously demonstrated in a preclinical model of critical limb ischemia, and their pericytic identity shall be further elaborated.

Research interest in short

1. Engineering of bio-instructive biomaterials to guide regeneration processes
2. Deciphering of the extracellular matrix
3. Blood-derived angiogenic cells (BDACs), their pericytic identity and their potential for clinical application

Selected Publications

1. Blocki A, Löper F, Chirico N, T Neffe A, Jung F, Stamm C, Lendlein A. Engineering of cell-laden gelatin-based microcapsules for cell delivery and immobilization in regenerative therapies. Clin Hemorheol Microcirc. 2017 Sep 4. doi: 10.3233/CH-179206. [Epub ahead of print]

2. A Blocki, C Löwenberg, Y Jiang, K Kratz, AT Neffe, F Jung, A Lendlein. Response of encapsulated cells to a gelatin matrix with varied bulk and microenvironmental elastic properties. Polymers for Advanced Technologies, 28 (10), 1245-1251 2016

3. P Peh, NSJ Lim, A Blocki, SML Chee, HC Park, S Liao, C Chan et al. Simultaneous delivery of highly diverse bioactive compounds from blend electrospun fibers for skin wound healing. Bioconjugate chemistry 26 (7), 1348-1358 2015

4. A Blocki, S Beyer, JY Dewavrin, A Goralczyk, Y Wang, P Peh, M Ng et al. Microcapsules engineered to support mesenchymal stem cell (MSC) survival and proliferation enable long-term retention of MSCs in infarcted myocardium. Biomaterials 53, 12-24 2015

5. JY Dewavrin, M Abdurrahiem, A Blocki, M Musib, F Piazza, M Raghunath. Synergistic Rate Boosting of Collagen Fibrillogenesis in Heterogeneous Mixtures of Crowding Agents. The Journal of Physical Chemistry B 119 (12), 4350-4358 2015

6. A Blocki, Y Wang, M Koch, A Goralczyk, S Beyer, N Agarwal, M Lee et al. Sourcing of an Alternative Pericyte-Like Cell Type from Peripheral Blood in Clinically Relevant Numbers for Therapeutic Angiogenic Applications. Molecular Therapy 23 (3), 510-522 2015

7. R Rashid, S Beyer, A Blocki, C Le Visage, D Trau, T Wohland et al. Mitochondrial Routing of Glucose and Sucrose Polymers after Pinocytotic Uptake: Avenues for Drug Delivery. Biomacromolecules 15 (6), 2119-2127 2014

8. XM Ang, MHC Lee, A Blocki, C Chen, LLS Ong, HH Asada, A Sheppard et al. Macromolecular crowding amplifies adipogenesis of human bone marrow-derived mesenchymal stem cells by enhancing the pro-adipogenic microenvironment. Tissue Engineering Part A 20 (5-6), 966-981 2013

9. A Blocki, Y Wang, M Koch, P Peh, S Beyer, P Law, J Hui, M Raghunath. Not all MSCs can act as pericytes: functional in vitro assays to distinguish pericytes from other mesenchymal stem cells in angiogenesis. Stem cells and development 22 (17), 2347-2355 2013

10. C Chen, F Loe, A Blocki, Y Peng, M Raghunath. Applying macromolecular crowding to enhance extracellular matrix deposition and its remodeling in vitro for tissue engineering and cell-based therapies. Advanced drug delivery reviews 63 (4), 277-290 2011