Professional Info

Prof. CHAN, Wai Yee

(Director)

Personal Information

Pro-Vice-Chancellor / Vice-President of The Chinese University of Hong Kong

Director of the Institute for Tissue Engineering and Regenerative Medicine

Office: (852) 3943 1383
Email: chanwy@cuhk.edu.hk
Address: Room G03A, G/F, Lo Kwee-Seong Integrated Biomedical Science Building, Area 39, CUHK

Research Interests

1. Functional genomics and epigenetic regulation of germ cell development in health and diseases
2. Functional genomics of developing male gonad
3. Molecular genetics of human endocrine disorders
4. Non-coding RNA, antisense transcript, and microRNA in normal and abnormal development
5. Genetics and genomics of fetal development

Selected Publications

1. Cheung, H. H., Lee, T. L., Davis, A. J., Taft, D. H., Rennert, O. M., & Chan, W. Y.(2010). Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer. British Journal of Cancer, 102(2), 419-427.

2. Cheung, H. H., Davis, A. J., Lee T. L., Pang, A. L., Nagrani, S., Rennert, O. M., & Chan, W. Y. (2011). Methylation of an intronic region regulates miR-199a in testicular tumor malignancy. Oncogene, 30(31), 3405-3415.

3. Lee, T. L., Raitano, J. M., Rennert, O. M., Chan, S. W., & Chan, W. Y. (2012). Accessing the genomic effects of naked nanoceria in murine neuronal cells. Nanomedicine, 8(5), 599-608.

4. Kaipparettu, B. A., Ma, Y., Park, J. H., Lee, T. L., Zhang, Y., Yotnda, P., Creighton, C. J., Chan, W. Y., & Wong, L. J. (2013). Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways. PLoS One, 8(5), e61747.

5. Gu, S., Cheung, H. H., Lee, T. L., Lu, G., Poon, W. S., & Chan, W. Y. (2013). Molecular mechanisms of regulation and action of microRNA-199a in testicular germ cell tumor and glioblastomas. PLoS One, 8(12), e83980.

6. Tsang, W. H., Wang, B., Wong, W. K., Shi, S., Chen, X., He, X. J., Gu, S., Hu, J. B., Wang, C.D., Liu, P.C., Lu, G., Chen, X. F., Zhao, H., Poon, W. S., Chan, W. Y., & Feng, B. (2013). LIF-dependent primitive neural stem cells derived from mouse ES cells represent a reversible stage of neural commitment. Stem Cell Research, 11(3), 1091-1102.

7. Chen, B. F., Gu, S., Suen, Y. K., Li, L., & Chan, W. Y. (2014). MicroRNA-199a-3p, DNMT3A and aberrant DNA methylation in testicular cancer. Epigenetics, 9(1), 119-128.

8. Chen, B., & Chan, W. Y. (2014). The de novo DNA methyltransferase DNMT3A in development and cancer. Epigenetics, 9(5), 669-677.

9. Chen, B. F., Suen, Y. K., Gu, S., Li, L., & Chan, W. Y. (2014). A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor. Scientific Reports, 4, 6413.

10. Chen, X., Gu, S., Chen, B. F., Shen, W. L., Yin, Z., Xu, G. W., Hu, J.J., Zhu, T., Li, G., Wan, C., Ouyang, H. W. , Lee, T. L., & Chan, W. Y. (2015). Nanoparticle delivery of stable miR-199a-5p agomir improves the osteogenesis of human mesenchymal stem cells via the HIF1a pathway. Biomaterials, 53, 239-250.

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